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A Comparison of the Cardiovascular Effects of Proscillaridin and Ouabain in Anaesthetised Dogs
Author(s) -
Angus J. A.,
Richmond D. R.,
Cobbin L. B.,
Goodman A. H.
Publication year - 1973
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1973.tb03114.x
Subject(s) - ouabain , medicine , contractility , inotrope , bradycardia , heart rate , blood pressure , anesthesia , cardiology , sodium , chemistry , organic chemistry
Summary: The activities of ouabain and proscillaridin (20, erg/kg) were compared in the dog. The two glycosides produced equal positive inotropic effects, a peak increase of myocardial contractility of approximately 20% being recorded at 20 to 30 minutes after their administration and for a further 30 minutes thereafter. Both drugs produced small immediate increases in systemic arterial blood pressure which fell below control levels 30 minutes after ouabain, and at a slower rate after proscillaridin. The bradycardia produced by ouabain was approximately twice that following proscillaridin. Both glycosides produced insignificant in‐creases in the PR interval and no difference on AV conduction could be detected between the two drugs during atrial pacing.