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The Increased Rate of Loss, and Non‐Exponential Excretion of Bile Salts in Patients with Tropical Sprue and lleectomy
Author(s) -
Kapadia C. R.,
Baker S. J.
Publication year - 1973
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1973.tb03092.x
Subject(s) - excretion , sprue , tropical sprue , medicine , gastroenterology , reabsorption , feces , steatorrhea , endocrinology , biology , microbiology and biotechnology , botany , mold , kidney
Summary: Cholic acid‐carboxy/ 14 C was administered to five control subjects, seven patients with tropical sprue and two patients with ileal resection and the daily excretion of the label in the faeces measured for seven to 13 days. Contrary to previous assumptions, the excretion was not always exponential. The practice of calculating decay constants from faecal excretion studies is therefore not valid. Four out of seven patients with sprue had an increased rate of excretion of the label, which in two subjects was similar to that of the patients with ileal resection. This indicates defective reabsorption of bile salts and may contribute to the pathogenesis of the steatorrhoea of tropical sprue.