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Effect of Cholecystokinin and Secretin on Gastric Hypersecretion in a Patient with the Zollinger‐Ellison Syndrome
Author(s) -
Gallagher N. D.,
Stening G. F.
Publication year - 1972
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1972.tb03943.x
Subject(s) - secretin , medicine , zollinger ellison syndrome , cholecystokinin , gastrin , gastric acid , gastrectomy , bicarbonate , gastroenterology , gastrointestinal hormone , endocrinology , achlorhydria , secretion , stomach , peptide hormone , hormone , cancer , receptor
Summary: The intravenous injection of cholecystokinin in a patient with the Zollinger‐Ellison syndrome resulted in a sharp fall in gastric acid secretion. In contrast, secretin infusion led to a further increase in the hypersecretion of acid. The latter effect is attributed to the release of extragastric gastrin for secretin infusion following total gastrectomy led to a further elevation of serum gastrin levels. Infusion of either cholecystokinin or secretin produced large volumes of bicarbonate‐rich duodenal juice.