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Oxyphenisatin Jaundice: Report of Two Probable Cases, One Fatal
Author(s) -
Saltos N.,
Duggan J. M.
Publication year - 1972
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1972.tb03941.x
Subject(s) - medicine , jaundice , hepatitis , laxative , gastroenterology , antibody , toxic hepatitis , immunology , constipation
Summary: Two patients with clinical, biochemical and histological evidence of hepatitis are described. Both patients were women taking laxative preparations containing oxyphenisatin. One, a sixty‐two‐year‐old died of liver cell failure with gross histological change in the liver at necropsy. This is apparently the first report of a fatal outcome following exposure to oxyphenisatin. The second patient had a milder illness and immunological changes with anti‐nuclear factor, smooth muscle antibodies and a positive RA and LE latex test, but in spite of the resemblance to active chronic hepatitis, the histological change rapidly resolved when oxyphenisatin exposure ceased. Hepatitis occurring in association with laxatives will be misdiagnosed unless the patients are directly questioned about their laxative habits.