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Azathioprine and Acute Restrictive Lung Disease
Author(s) -
Rubin George,
Baume Peter,
Vandenberg Russell
Publication year - 1972
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1972.tb03074.x
Subject(s) - medicine , azathioprine , intensive care medicine , lung disease , lung , disease
Summary: A 20‐year‐old male patient with ulcerative colitis is thought to have developed acute restrictive lung disease as a consequence of azathioprine therapy. After taking azathioprine for six weeks in a daily dose of 100 mg, the patient developed a dry cough and rapidly increasing exertional dyspnoea. Chest x‐ray film revealed basal shadowing. Spirometric studies showed a severe reduction in vital capacity and F.E.V. 1.0 second of restrictive pattern. Carbon monoxide gas transfer was 53% of predicted normal. Following cessation of the drug symptoms disappeared and respiratory function returned to normal.