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Halothane Hepatitis in a Laboratory Technician
Author(s) -
Johnston C. I.,
Mendelsohn F.
Publication year - 1971
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1971.tb02285.x
Subject(s) - medicine , malaise , anorexia , jaundice , hepatitis , vomiting , rash , halothane , dermatology , technician , eosinophilic , liver biopsy , surgery , biopsy , gastroenterology , anesthesia , pathology , electrical engineering , engineering
Summary A case report of hepatitis attributable to halothane in a laboratory technician is reported. The patient had been using the drug to anaesthetise rats for experimental procedures. Her initial illness was one of malaise, anorexia and vomiting. However on re‐exposure she developed an accelerated reaction characterised by fever, rigors, rash, body aches and malaise, followed by jaundice. Liver biopsy showed a hepati‐tic picture with prominent eosinophilic infiltrate. Her Australian antigen was negative as well as tests for mitochondrial antibody. The patient made a rapid uneventful recovery.