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Plasma Levels and Urinary Excretion of Nalidixic Acid in Patients with Renal Failure *
Author(s) -
Adam W. R.,
Dawborn J. K.
Publication year - 1971
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1971.tb02278.x
Subject(s) - nalidixic acid , medicine , renal function , urine , excretion , renal physiology , sodium bicarbonate , urinary system , clearance , bicarbonate , urology , pharmacology , endocrinology , antibiotics , biochemistry , ciprofloxacin , chemistry
Summary: The excretion of nalidixic acid (α 1, 8, naphthyridine) has been studied in patients with renal impairment. The clearance of the therapeutically active naphthyridines was not related to renal function. The clearance of inactive conjugates of nalidixic acid was decreased in patients with renal failure resulting in a rise in plasma levels during continuous therapy. Despite severe renal failure therapeutic levels of active naphthyridines in the urine were usually obtained. Sodium bicarbonate administered orally in conjunction with nalidixic acid appeared to increase the absorption and the urinary clearance of the active naphthyridines.