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Prognostic significance of tumour markers in C hinese patients with gastric cancer
Author(s) -
Liu Xiaowen,
Cai Hong,
Wang Yag
Publication year - 2014
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2012.06287.x
Subject(s) - medicine , pathological , carcinoembryonic antigen , lymphovascular invasion , stage (stratigraphy) , cancer , lymphatic system , gastrectomy , pathology , gastroenterology , pathological staging , multivariate analysis , metastasis , biology , paleontology
Background and objectives The clinical value of preoperative tumour markers remains elusive in gastric cancer. The aim of this study was to investigate the prognostic value of alpha‐fetoprotein ( AFP ), carcinoembryonic antigen ( CEA ), carbohydrate antigen ( CA )19‐9, CA 50 and CA 72‐4 in gastric cancer. Methods About 391 gastric cancer patients who underwent curative D 2 gastrectomy between 2001 and 2006 were evaluated. The correlation between tumour markers and clinicopathologic characteristics and prognostic value of preoperative tumour markers was investigated. Results Correlation analysis showed that AFP was associated with tumour size ( P = 0.040); CEA with lymphatic invasion ( P = 0.023) and pathological stage ( P = 0.018); CA 19‐9 with tumour size ( P = 0.000), B orrmann type ( P = 0.027), lymphatic invasion ( P = 0.020) and pathological stage ( P = 0.001); CA 50 with lymphatic invasion ( P = 0.004) and pathological stage ( P = 0.004); CA 72‐4 with tumour size ( P = 0.000), tumour size ( P = 0.000) and B orrmann type ( P = 0.008); lymphatic invasion ( P = 0.000), nervous invasion ( P = 0.028) and pathological stage ( P = 0.000). Multivariate analysis showed that CEA , tumour site, B orrmann type and pathological stage were independent prognostic factors. Conclusions Preoperative CEA might be a candidate for the staging system in addition to conventional factors.