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Enhanced random skin flap survival by sustained delivery of fibroblast growth factor 2 in rats
Author(s) -
Park Hyoung Joon,
Lee Seahyoung,
Kang Kyo Hwa,
Heo Chan Yeong,
Kim Ji Hoon,
Yang Hee Seok,
Kim ByungSoo
Publication year - 2013
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2012.06194.x
Subject(s) - medicine , skin flap , fibroblast growth factor , surgery , fibrin , plastic surgery , saline , wound healing , angiogenesis , basic fibroblast growth factor , fibroblast , heparin , growth factor , anesthesia , immunology , chemistry , receptor , biochemistry , in vitro
Background Skin flap survival is a major challenge in reconstructive plastic surgery. Here, we examined the effect of sustained delivery of fibroblast growth factor 2 ( FGF 2) using heparin‐conjugated fibrin ( HCF ) on skin flap survival in rats. Methods Rats with a skin flap received either phosphate‐buffered saline/ FGF 2 or HCF / FGF 2 in the recipient bed. For the no‐treatment group, a random skin flap was sutured on the back without any treatment. Seven days after surgery, angiogenesis in the skin flap was evaluated by using V isitrak system and conventional healing quality scoring method. The efficacy of HCF / FGF2 in skin flap survival was evaluated by comparing the results from different groups. Results The necrotic area of the skin flap significantly decreased in the HCF / FGF2 group as compared with the other groups. Conclusion The sustained delivery of FGF2 using HCF has a therapeutic potential to improve skin flap survival.
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