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Microarray: an instrument for cancer surgeons of the future?
Author(s) -
Broadhead Matthew L.,
Clark Jonathan C. M.,
Dass Crispin R.,
Choong Peter F. M.
Publication year - 2010
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2010.05379.x
Subject(s) - microarray , medicine , microarray analysis techniques , malignancy , cancer , pancreatic cancer , tissue microarray , prostate cancer , bioinformatics , computational biology , pathology , gene , gene expression , biology , genetics
Microarray enables the study of thousands of genes simultaneously. While still in its infancy as a technique and with a number of barriers to be overcome, microarray is allowing scientists to thoroughly examine the molecular pathways of cancer pathogenesis. However, the adoption of microarray as a clinically applicable technique has been slow coming. Current literature suggests roles in the diagnosis of tumours of unknown origin, in the evaluation of prognostic markers, and in guiding treatment for recurrent and resistant malignancy. This review outlines the science of microarray and draws on clinical examples, including osteosarcoma, breast, prostate and pancreatic carcinomas, to highlight the potential of microarray as a technique of surgical importance.