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Outcome following surgery for squamous cell carcinoma of the oesophagus
Author(s) -
Yong En Loon C.,
Han Xing Peng,
Watson David I.,
Devitt Peter G.,
Jamieson Glyn G.,
Thompson Sarah K.
Publication year - 2009
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2009.05058.x
Subject(s) - medicine , basal cell , carcinoma , general surgery , surgery , oncology
This study was undertaken to determine the outcomes of patients treated for squamous cell carcinoma (SCC) of the oesophagus. Methods: The study group consisted of 61 patients (median age: 64 years) with invasive SCC of the oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty‐two (52%) were female. Survival data were available for all patients. The log rank test was performed to identify prognostic factors for survival. Results: The 5‐year overall survival rate was 33% (median: 24 months). Of 61 patients, 42 (69%) received neoadjuvant therapy prior to surgery. The overall resection rate was 95%. Significant post‐operative morbidity occurred in 47%, and the in‐hospital mortality was 5% (30‐day mortality: 3%). No overall survival benefit was seen in patients undergoing neoadjuvant therapy prior to surgical resection. However, patients who had a complete pathological response to neoadjuvant therapy had a better 5‐year survival than patients who did not receive neoadjuvant therapy: 47% versus 30%, respectively. Conclusions: Oesophagectomy following neoadjuvant therapy for SCC of the oesophagus can be performed with low perioperative mortality. A complete response to neoadjuvant therapy was followed by an improved survival outcome.