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Soluble Human Leukocyte Antigen class I antigen and interleukin‐12 in hepatectomized patients
Author(s) -
Shimura Tatsuo,
Morinaga Nobuhiro,
Suzuki Hideki,
Araki Kenichiro,
Kobayashi Tsutomu,
Ishizaki Masatoshi,
Kuwano Hiroyuki
Publication year - 2009
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2009.04947.x
Subject(s) - medicine , ctl* , hepatectomy , fresh frozen plasma , gastroenterology , cytotoxic t cell , immunology , antigen , cytotoxicity , surgery , cd8 , biochemistry , platelet , chemistry , resection , in vitro
Background: Interleukin‐12 (IL‐12) has been shown to enhance the cytotoxic activity of NK cells and CTL. IL‐12 also acts as a growth factor for activated NK, T and NKT cells. The soluble HLA class I (sHLA‐I) has been reported to bind a killer‐cell inhibitory receptor, which is expressed on the NK cell, and its signals inhibit NK cell‐mediated cytotoxicity. Effects of fresh frozen plasma (FFP) on post‐operative immune status have not yet been completely examined. Methods: Thirty consecutive patients taking a hepatectomy were enrolled. The levels of IL‐12 and sHLA‐I were examined by enzyme‐linked immunosorbent assay. Results: The rate of complication after hepatectomy in the FFP‐administered patients was higher than that in patients without FFP administration ( P = 0.0358). Decreased IL‐12 levels after surgery in patients without FFP administration recovered to the preoperative state earlier than those in patients with FFP administration ( P < 0.05). The levels of sHLA‐I in the FFP‐administered patients were higher than those in the patients without FFP administration ( P < 0.05). Conclusions: Administration of FFP, which contains sHLA‐I, affected the levels of sHLA‐I after hepatectomy. Both high levels of sHLA‐I and low levels of IL‐12 could attenuate NK activities after hepatectomy, especially when FFP would be administered.