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FACTORS AFFECTING FALSE‐NEGATIVE BREAST SENTINEL NODE BIOPSY IN CHINESE PATIENTS *
Author(s) -
Chok Kenneth S. H.,
Suen Dacita T. K.,
Lim Fiona M. Y.,
Li George K. H.,
Kwong Ava
Publication year - 2007
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2007.04260.x
Subject(s) - medicine , sentinel lymph node , breast cancer , odds ratio , biopsy , retrospective cohort study , confidence interval , axillary lymph node dissection , univariate analysis , sentinel node , lymph , radiology , surgery , multivariate analysis , cancer , pathology
Background: The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false‐negative (FN) rates of SLNB in Chinese patients with invasive breast cancers. Methods: A retrospective study of patients with clinically node‐negative invasive breast cancer was carried out from May 1999 to April 2006. A combination of radioisotope 99m technetium(Tc)‐albumin sulfur colloid and Patent Blue V dye was used to identify the sentinel lymph node. Sentinel lymph node biopsy was followed by standard level I and II axillary dissection in all patients. Various clinicopathologic variables were analysed to determine factors associated with FN SLNB. Results: Three hundred and sixty‐five Chinese patients received SLNB consecutively during the study period. Seventy‐eight patients with neoadjuvant chemotherapy and 56 patients with in situ carcinoma were excluded. A total of 231 patients were studied. Sentinel lymph nodes were identified in 221 patients (95.7%). There were 10 FN, resulting in a FN rate of 12.5% and accuracy rate of 95.5%. Only the number of sentinel lymph node harvested was found to be a significant factor affecting FN rates on univariate ( P < 0.009) and multivariate logistic regression (odds ratio: 2.65; 95% confidence interval: 2.57–2.73; P < 0.000). Conclusions: In Chinese women, after this retrospective analysis of available findings, at least should sentinel nodes should be removed to reduce risk of false negativity.