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AORTIC CALCIFICATION: STUDIES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE AND A MOUSE MODEL
Author(s) -
Golledge J.,
Pal S.,
Jayalath R.,
Van Campenhout A.,
Clancy P.,
Rush C.
Publication year - 2007
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2007.04134_2.x
Subject(s) - medicine , calcification , peripheral , cardiology , radiology , pathogenesis , disease , aorta , calcinosis , pathology
Purpose Aortic calcification is associated with subsequent cardiovascular events however relatively little is understood about its pathogenesis. This presentation describes on‐going work to improve measurement, diagnosis and understanding of aortic calcification. Methodology Studies have been carried out in a cohort of patients with peripheral artery disease and within an animal model. Results We have developed and validated a technique to accurately assess the severity of infrarenal abdominal aortic calcification using CT angiography within patients. Utilising this technique we have investigated a number of potential blood tests to assess their value in determining aortic calcification severity. Within a mouse model of aortic calcification we are investigating the role of bone marrow derived cells in calcification development. Conclusions Further understanding of the mechanisms underlying aortic calcification may identify targets to treat calcification which are independent of those for atherosclerosis.