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SONIC HEDGEGHOG PATHWAY – A POSIBLE THERAPEUTIC TARGET FOR HEPATOBLASTOMA
Author(s) -
Arsic D.,
Sullivan M. J.,
Beasley S. W.
Publication year - 2007
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2007.04125_12.x
Subject(s) - hepatoblastoma , hedgehog signaling pathway , medicine , cancer research , hedgehog , sonic hedgehog , blockade , signal transduction , microbiology and biotechnology , biology , receptor
Background and Objectives It has been shown that the hedgehog (Hh) signalling pathway that is turned off once organogenesis is complete in the embryo is re‐activated in a number of different cancers. We analyzed re‐activation of the Hh pathway in hepatoblastoma to investigate whether this pathway can be used as a therapeutic target. Methods Surgically resected hepatoblastoma specimens and hepatoblastoma cell lines were analyzed by immunoblot and PCR, looking into different components of the pathway. Results We found that pharmacological pathway blockade leads to decreased cell proliferation in hepatoblastoma cells, demonstrating an ongoing requirement of Hh signalling in this tumour. Conclusion The Hh pathway may be a useful therapeutic target for hepatoblastoma and other tumours in which the Hh pathway (or a component of the pathway) are over‐expressed or re‐activated at an inappropriate time.