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RISK FACTORS FOR MICROVASCULAR TUMOUR THROMBI IN HEPATOCELLULAR CARCINOMA: A UNIVARIATE AND MULTIVARIATE ANALYSIS
Author(s) -
Ibrahim Salleh,
Roychowdhury Anupama,
Khoon Hean Tay
Publication year - 2007
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2006.03995.x
Subject(s) - medicine , univariate , multivariate analysis , hepatocellular carcinoma , univariate analysis , multivariate statistics , oncology , carcinoma , statistics , mathematics
Background: Microvascular tumour thrombi in hepatocellular carcinoma (HCC) predict poor outcome and are a risk factor for intrahepatic and extrahepatic metastases. Survival after liver transplantation is also affected. Our aim was to predict the risk factors for the presence of microvascular tumour thrombi. Methods: Seventy‐six patients who had undergone hepatectomy for HCC in our hospital were included in a retrospective analysis from a prospective database. Results: Thirty‐one patients (40.8%; mean age 50.7 ± 12.2 years, P < 0.021) had microvascular tumour thrombi (group T) and 54 patients (group NT; mean age 58.6 ± 15.4 years) did not. Using logistic regression analysis, we found that more than one HCC nodule, a large tumour, chronic hepatitis C infection and high serum aspartate aminotransferaselevels were significant risk factors for microvascular tumour thrombi. Age, preoperative serum bilirubin level and sex were not significant risk factors. Conclusion: Patients with chronic hepatitis C infection having multiple HCC nodules, large tumour size and high preoperative aspartate aminotransferase levels are at high risk for microvascular tumour thrombi.