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DOES MATRIX METALLOPROTEINASE ACTIVITY PREDICT SEVERITY OF ACUTE PANCREATITIS?
Author(s) -
Aynaci Murat,
Tuncyurek Pars,
Nart Deniz,
Zeytunlu Murat,
Ozutemiz Omer,
Ersoz Galip,
Yilmaz Funda,
Mayer Jens,
Coker Ahmet
Publication year - 2006
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2006.03871.x
Subject(s) - medicine , acute pancreatitis , pancreatitis , matrix metalloproteinase , histology , pancreas , inflammation , gastroenterology , pancreatic disease , matrix metalloproteinase 9 , pathology
Background: Matrix metalloproteinases (MMP) modulate end‐organ complications of acute pancreatitis, but the correlation between increased MMP production and histological severity of disease remains unclear. We examined the role of MMP and pancreas histology on experimental acute pancreatitis. Methods: Forty male Wistar albino rats were subjected to cerulein‐induced pancreatitis (8, 16, 24 and 32 h groups) or sham treatment. The animals were killed at different time points and pancreatic tissues were harvested to assess MMP (1, 2 and 9) activity and inflammatory changes. Results: Compared with other groups, 8 h group had decreased tissue MMP‐1 concentrations. MMP‐9 concentrations were lower in 24‐h and 32‐h groups, as were histological severity scores. MMP‐2 activity did not differ among groups. Pancreatitis was prominent in 8‐h, 16‐h and 24‐h groups by means of histology. Conclusion: Induction of pancreatitis by cerulein altered pancreatic MMP levels in the early phase of inflammation. Inhibition of MMP‐2 and MMP‐9 paralleled histological scores. Therefore, MMP may have a predictive value to assess histological severity.