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EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER
Author(s) -
Saito Hiroaki,
Osaki Tomohiro,
Murakami Daiki,
Sakamoto Teruhisa,
Kanaji Shingo,
Tatebe Shigeru,
Tsujitani Shunichi,
Ikeguchi Masahide
Publication year - 2006
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2006.03756.x
Subject(s) - medicine , incidence (geometry) , cancer , lymph node , multivariate analysis , gastroenterology , gastrectomy , dissection (medical) , lymph node metastasis , metastasis , oncology , surgery , physics , optics
Background: The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive. Methods: A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age. Results: Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients ( P < 0.0001) and elderly patients underwent limited lymph node dissection compared with nonelderly patients ( P < 0.001). Moreover, chemotherapy was carried out in nonelderly patients more frequently than in elderly patients ( P < 0.005). Ten‐year survival rates were 70.2 and 81.4% in elderly and nonelderly patients, respectively, and the differences were statistically significant ( P < 0.001). Postoperative mortality rates were 3.2 and 2.0% in elderly and nonelderly patients, respectively. Hematogenous recurrence was more frequently observed in elderly patients than nonelderly patients ( P < 0.05). Multivariate analysis showed that age was an independent prognostic factor. Conclusions: Age clinically serves as a simple predictor of survival in patients with gastric cancer and should be taken into account along with conventional clinicopathological variables such as depth of invasion and lymph node metastasis.