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REVIEW OF PATIENTS WITH PERITONEAL MALIGNANCY TREATED WITH PERITONECTOMY AND HEATED INTRAPERITONEAL CHEMOTHERAPY
Author(s) -
Hadi Reema,
Saunders Vanessa,
Utkina Olga,
Clingan Philip,
Kam Peter,
Links Matthew,
Morris David L.
Publication year - 2006
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2006.03579.x
Subject(s) - medicine , surgery , conventional pci , oxaliplatin , intraperitoneal chemotherapy , peritoneal mesothelioma , ovarian cancer , malignancy , survival rate , colorectal cancer , mesothelioma , pseudomyxoma peritonei , hyperthermic intraperitoneal chemotherapy , chemotherapy , cancer , appendix , cytoreductive surgery , myocardial infarction , paleontology , pathology , biology
Background: Peritoneal dissemination of malignancy is usually considered incurable. The purpose of the present study was to evaluate the efficacy of intraperitoneal chemohyperthermia and cytoreductive surgery. Methods: The present article is a retrospective review of prospectively recorded data in 60 patients who underwent 71 peritonectomy procedures between January 1996 and May 2004. Hospital records, a database and department notes were studied. Conditions treated were pseudomyxoma peritoneii (PMP) and appendiceal cancer (23), mesothelioma (7), colorectal cancer (CRC, 15), ovarian cancer (6) and other forms of malignancy (9). Following cytoreductive surgery, early postoperative intraperitoneal chemotherapy (EPIC) was given in 47 procedures, five with added i.v. mitomycin C. In 34 procedures, heated intraperitoneal chemotherapy (HIPEC) was administered. A policy change was made from intravenous to intraperitoneal mitomycin C chemotherapy in December 2001. Peritoneal cancer index (PCI) was calculated for all procedures. Results: Of the procedures, 23 had PCI ≤ 10, 37 had PCI of 11–20, and 11 had PCI > 20. The median operation time was 9 h. Blood units transfused and length of hospital stay have declined. Mortality was 4/60 patients (6.7%), caused by pancytopenia and sepsis. Morbidity occurred in 28/71 procedures. The 3‐year survival rate for the HIPEC group was 71% compared with 28% for the no HIPEC group. In the complete excision group, the 3‐year survival rate was 52% compared with 13% for the incomplete excision group. The 3‐year survival rate for PMP and appendiceal cancer was 74%. The 2‐year survival rate for ovarian cancer was 67%, mesothelioma 57%, and CRC 50%, respectively. Conclusions: Morbidity is significantly associated with duration of surgery and units of blood transfused. Our findings are consistent with the international experience in patients treated with combined peritonectomy and HIPEC.