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Effects of Seprafilm on peritoneal fibrinolytic system
Author(s) -
Tarhan Omer Ridvan,
Eroglu Aydan,
Cetin Recep,
Ynce Ayper,
Bulbul Mahmut,
Altuntas Yrfan
Publication year - 2005
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/j.1445-2197.2005.03483.x
Subject(s) - medicine , peritoneal diseases , intensive care medicine , surgery
Background: There is a high incidence of adhesions after ventral hernia repair with polypropylene mesh. The purpose of the present study was to evaluate the efficacy of Seprafilm in the prevention of adhesion formation and effect on peritoneal fibrinolytic activity. Methods: An incisional hernia model was created in rats. In the experimental group Seprafilm was placed between polypropylene mesh and abdominal organs. On the 14th day adhesions were evaluated and tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), plasminogen activator inhibitor (PAI) type 1 and 2 were measured in peritoneal biopsy specimens. Results: Adhesions were significantly reduced in the Seprafilm group ( P = 0.002). Nevertheless, there were no difference between the two groups in levels of tPA, PAI‐1 and PAI‐2. However, the levels of uPA were significantly decreased in the Seprafilm group. Conclusions: The adhesion preventive effect of Seprafilm is not directly related in peritoneal fibrinolytic activity. Instead, the physical properties (barrier, hydroflotation and sliconizing effect) of the membrane are primarily responsible for adhesion prevention.