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PROLONGED SURVIVAL FOLLOWS RESECTION OF OESOPHAGEAL SCC DOWNSTAGED BY PRIOR CHEMORADIOTHERAPY
Author(s) -
Bessell J. R.,
Devitt P. G.,
Gill P. G.,
Goyal S.,
Jamieson G. G.
Publication year - 1996
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1996.tb01167.x
Subject(s) - medicine , chemoradiotherapy , surgery , lymphadenectomy , pathological , lymph node , radiation therapy , carcinoma , survival rate , radiology
Background: The poor survival rate of surgically treated patients with oesophageal cancer has not improved substantially over the last 25 years, but combined modality therapy has shown early promising results. Methods: A prospective study was undertaken to determine the effect of pre‐operati ve synchronous chemoradiotherapy followed by oesophagectomy in 53 patients with squamous cell carcinoma (SCC) of the oesophagus. The patient group was unselected, other than by fitness for surgery. Results: In 25% of patients, complete pathological regression of the tumour was achieved. All but one of the patients in this subgroup had T2 tumours on pre‐operative clinical staging and two had evidence of lymph node involvement, but postoperative pathological examination revealed that pre‐operative chemoradiotherapy had downstaged their disease to TONO. There was no hospital mortality in this subgroup and the actuarial 7 year survival was 69%. Conclusions: For squarnous oesophageal tumours deep to the submucosa this is an extremely good survival. For the present, this form of therapy for SCC of the oesophagus appears capable of achieving results comparable to, or better than, those reported for 3‐field lymphadenectomy.