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HIGH DOSE LOPERAMIDE SUPPOSITORIES: A NOVEL APPROACH FOR IMPROVING CLINICAL FUNCTION AFTER RESTORATIVE PROCTOCOLECTOMY
Author(s) -
Levitt M. D.,
Jenner D. C.,
Maher M. J.
Publication year - 1995
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1995.tb00580.x
Subject(s) - medicine , loperamide , pouch , placebo , proctocolectomy , crossover study , ulcerative colitis , familial adenomatous polyposis , ileostomy , suppository , gastroenterology , surgery , diarrhea , colorectal cancer , pharmacology , alternative medicine , disease , pathology , cancer
The effect of loperamide suppositories on patients following restorative proctocolectomy was studied by means of a randomized, double‐blind, crossover trial comparing active suppositories (20 mg b. d. X 1 week) with placebo. Ten patients (8 male, 2 female; 7 J pouch, 3 W pouch; 8 ulcerative colitis, 2 familial adenomatous polyposis) were studied 3–60 months (median, 31.5) after ileostomy closure. Ages ranged from 24 to 63 years (median, 41.5). All patients kept a diary of their bowel habits and eight underwent a standardized test of pouch compliance. Urgency volume (UV) and maximum tolerable volumes (MTV) and the volume at onset of large isolated pouch contractions (LIC) were recorded. Statistical analysis was by the Wilcoxon test for paired data. Mean daily stool frequency during the placebo phase ranged from 3.7 to 7.8. It was reduced during the active phase in only seven patients ( P > 0.1) but was reduced in all six patients whose placebo phase stool frequency was five or more. Urgency volume was increased by use of active suppositories in six of the eight patients tested ( P > 0.1). There was no consistent effect on MTV. Large isolated pouch contractions were not seen in either test in one patient. In all of the remaining seven patients LIC were recorded after the placebo phase. After the active phase LIC first appeared at higher volumes in three but were not seen at all in four patients. High dose loperamide suppositories suppress pouch contractions and tend to lower stool frequency especially when high initially. They represent a novel therapeutic approach to high stool frequency in pouch patients.