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INHIBITION OF WOUND CONTRACTION BY TOPICAL ANTIMICROBIALS
Author(s) -
Leitch Ian O. W.,
Kucukcelebi Ahmet,
Robson Martin C.
Publication year - 1993
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1993.tb00385.x
Subject(s) - silver sulfadiazine , medicine , antimicrobial , contraction (grammar) , wound healing , in vitro , in vivo , sulfadiazine , pharmacology , microbiology and biotechnology , surgery , antibiotics , biochemistry , biology
Spontaneous wound healing occurs partly by wound contraction, a process that requires intact functioning fibroblasts, and collagen production. Disruption of fibroblasts by the topical antimicrobials, silver sulfadiazine and mafenide acetate has been demonstrated in vitro . An acute rat wound model was used to show that wound contraction in vivo is significantly impeded by silver sulfadiazine and mafenide acetate.