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PROPHYLAXIS AGAINST VENOUS THROMBOSIS AFTER TOTAL HIP ARTHROPLASTY
Author(s) -
Feller Julian A.,
Parkin John D.,
Phillips Gareth W.,
Han Peter J.,
Hennessy Oliver,
Huggins Richard M.
Publication year - 1992
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1992.tb07530.x
Subject(s) - medicine , warfarin , venography , anesthesia , venous thrombosis , thrombosis , surgery , pulmonary embolism , pulmonary embolus , cardiology , atrial fibrillation
Venous thrombosis rates were compared in 200 patients undergoing total hip arthroplasty and randomized to receive either fixed mini‐dose warfarin (1 mg daily) or adjusted‐dose warfarin to maintain an international normalized prothrombin ratio (INR) of 2.0–4.0. Bilateral lower limb venography was performed between days 11 and 13 inclusive. Fixed mini‐dose warfarin was associated with a significantly higher rate of total thrombosis ( P < 0.05). General anaesthesia was associated with a significantly higher rate of thrombosis than spinal anaesthesia ( P < 0.05). Adjusted‐dose warfarin was associated with more bleeding complications than mini‐dose warfarin although these were not attributable to excessive anticoagulation. A single death from pulmonary embolus occurred in the early postoperative period in a patient receiving adjusted‐dose warfarin.