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LONG SURVIVORS AFTER PANCREATODUODENECTOMY FOR PANCREAS HEAD CARCINOMA
Author(s) -
Yamaguchi Koji,
Nishihara Kazuyoshi,
Kolodziejczyk Piotr,
Tsuneyoshi Masazumi
Publication year - 1992
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1992.tb07048.x
Subject(s) - medicine , pancreas , head of pancreas , carcinoma , incidence (geometry) , metastasis , lymph node , pancreaticoduodenectomy , surgery , adenocarcinoma , univariate analysis , cancer , jaundice , lymph , multivariate analysis , pathology , physics , optics
Twelve Japanese patients with pancreas head carcinoma who survived 3 years or more after a pancreatoduodenectomy and 50 who survived less than 12 months were reviewed clinicopathologically. The 12 patients who survived for ≥ 3 years exhibited more favourable prognostic factors: a higher incidence of jaundice; a smaller mass; a higher prevalence of an earlier stage tumour and adenocarcinoma of differentiated type; and a lower incidence of venous invasion, lymph node metastasis, and cancer cells at the surgical margins. However the difference was not significant. Univariate log‐rank analysis regarding 13 prognostic variables showed that histologic type was a significant factor but multivariate Cox regression analysis failed to reveal an independent significant parameter. Nine of the 12 long‐term survivors showed lymph node metastasis and six of the 12 revealed cancer cells at the surgical margins. Six of the 12 long‐term survivors died from local recurrence and/or distant metastasis 37–78 months after operation. Only two patients survived more than 5 years after the operation. At the time of writing, one of them was still alive and another was dead 78 months after the operation. Pancreatoduodenectomy for pancreas head carcinoma infrequently offers a permanent cure for the patients with pancreas head carcinoma but sometimes produces a worthwhile long‐term survival, even if the resected margins were affected by malignant cells or the lymph node metastasis was evident.