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EFFECTS OF FUREGRELATE (UPJOHN 63557A) ON PATENCY AND PLATELET DEPOSITION AFTER CANINE CAROTID ENDARTERECTOMY
Author(s) -
Payne J. E.,
Langsfeld M.,
Joseph M.,
Huber D.,
GrayWeale A.,
Meyer J. H.,
Smith T.,
Lusby R. J.
Publication year - 1991
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1991.tb00303.x
Subject(s) - medicine , carotid endarterectomy , restenosis , platelet , thrombosis , endarterectomy , thromboxane , cardiology , stroke (engine) , platelet activation , carotid arteries , anesthesia , surgery , stent , mechanical engineering , engineering
Platelet deposition upon endarterectomy sites is a likely cause for early postoperative thrombosis, embolism and restenosis. Platelets aggregate by the thromboxane‐prostacycline mechanism. Thromboxane synthetase inhibitors which have been safely administered to humans should reduce platelet deposition after surgical therapy and therefore reduce pen‐operative mortality and the prevalence of stroke. A randomized prospective controlled trial was designed to determine vessel patency and platelet deposition associated with the use of 3 mg/kg and 30mg/kg of Furegrelate (Upjohn U63557A) daily in dogs, who were to have carotid endarterectomy. The 46 treated and 46 control dogs had total carotid patency of 96% and 76% respectively ( P < 0.01). Fourteen dogs treated with 30mg/kg Furegrelate had no occlusions, compared with a 19% prevalence in 13 controls ( P < 0.02). Furegrelate 10 mg/kg significantly lowered platelet aggregation. Platelet deposition was not significantly changed, however. The reason for this disparity was a probable persistence of vessel wall factors which promoted platelet deposition. This approach might therefore lower rates of peri‐operative thrombosis but it would be very unlikely to alter the incidence of restenosis or embolism. Further research could be directed towards modifying the stimuli for platelet deposition upon the endarterectomy site.