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PHARMACOLOGICAL MANIPULATION OF POSTOPERATIVE INTESTINAL ADHESIONS
Author(s) -
Spar AnthonyL.,
Spitz Lewis
Publication year - 1989
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1989.tb01665.x
Subject(s) - medicine , cisapride , anticholinergic , intestinal motility , motility , adhesion , ileus , stimulation , atropine , postoperative ileus , paralytic ileus , abdominal surgery , anticholinergic agents , gastroenterology , surgery , anesthesia , chemistry , organic chemistry , biology , genetics
Paralytic ileus and intestinal adhesions are common events following infra‐abdominal surgery. The theoretical hypothesis ‘that stimulation of the postoperative bowel will reduce intestinal adhesions’ was studied in a rat model for intestinal adhesions in which postoperative bowel motility was pharmacologically manipulated. Immediate postoperative stimulation of gastrointestinal motility by the prokinetic agent, cisapride, resulted in a significant reduction in both the number and extent of adhesions. Inhibition of postoperative intestinal motility with the anticholinergic agent, atropine, resulted in a greater number of more dense adhesions involving an increased length of bowel.