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REDUCTION IN AMPUTATION STUMP INFECTION BY ANTISEPTIC PRE‐OPERATIVE PREPARATION
Author(s) -
Payne JohnE.,
Breust Megan,
Bradbury Ross
Publication year - 1989
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1989.tb01647.x
Subject(s) - medicine , antiseptic , amputation , surgery , peripheral , randomization , vascular disease , economic shortage , retrospective cohort study , randomized controlled trial , pathology , linguistics , philosophy , government (linguistics)
The prevalence of ischaemic or infective delayed wound healing in amputations for peripheral vascular disease may vary from 18 to 40%. A prospective trial to test the efficacy of 12h preoperative preparation with 10% povidone‐iodine was performed in a 1‐year period, during which time 80 consecutive amputations were performed on 73 patients. Accrual to the treatment arm was incomplete and was principally due to extreme nursing shortages. Failure of randomization resulted in the study being analysed as if it were retrospective. Infection occurred in 14 (23%) of unprepared limbs but was not found in any of the 19 prepared limbs ( p < 0.05). Infection occurred in 11 of 34 unprepared limbs which had distal ulcers or moist gangrenous lesions; however, 15 prepared limbs which had similar distal lesions had no infection ( p < 0.025). The reduction of wound breakdown and infection resulted in a significant reduction in hospitalization prior to commencement of prosthetic fitting ( p < 0.001). Preoperative antiseptic preparation played an important role in the reduction of infection following amputation for peripheral vascular disease, particularly for those patients whose amputation was required because of contaminated peripheral ischaemic lesions. However, these preliminary results should be confirmed by further study.