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BILATERAL TESTICULAR AND ADRENAL MALIGNANT LYMPHOMA OF PRE B‐CELL TYPE
Author(s) -
Coventry BrendonJ.,
Nacey JohnN.,
Orell Svante,
Marshall VillisR.,
Seshadri Ram
Publication year - 1989
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1989.tb01469.x
Subject(s) - medicine , lymphoma , pathology , bone marrow , lymph node , cd5 , chemotherapy , cytology , immunohistochemistry , lymphoblastic lymphoma , immunology , t cell , immune system
A rare case of pre b‐lymphoblastic lymphoma of the testes and adrenal glands is presented. No lymph node, central nervous system or bone marrow involvement was demonstrated at diagnosis. The primary presentation was of acute unilateral pain and swelling, mimicking simple orchitis. The diagnosis was made using aspiration cytology and the lymphoma characterized using immunohistochemical, electron microscopic and karyotype analysis techniques. Pre b‐cell markers were clearly demonstrated by all criteria used. Monoclonal antibodies (fmc 29 and fmc 31) were used to define the early b‐cell nature of the lymphoma. Confirmation using karyotype analysis in addition to immunoglobulin and t‐cell β‐receptor gene rearrangement was obtained. Intrathecal chemotherapy was used prophylactically. Combination chemotherapy produced regression of the primary lymphomatous lesions, but subsequent bone marrow spread led to death.