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RISK FACTORS FOR HALOTHANE HEPATITIS
Author(s) -
Cousins MichaelJ.,
Plummer JohnL.,
Hallt Pauline de la M.
Publication year - 1989
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1989.tb01457.x
Subject(s) - halothane , medicine , hypoxia (environmental) , hepatitis , complication , anesthesia , oxygen , chemistry , organic chemistry
Helothane hepatitis is a rare but sometimes fatal complication of halothane anaesthesia. Examination of case reports has pointed to a number of risk factors. Studies in animals and humans in the laboratory have provided evidence of a complex multifactorial basis for halothane hepatotoxicity, with the following factors playing a part: genetic predisposition; metabolism of halothane; repeated halothane anaesthetics; female sex; age of patient; intrahepatic hypoxia; and enzyme induction. Immunologic changes can be detected in a high percentage of cases of halothane hepatitis; however, studies establishing a cause‐effect relationship are not available to determine if these changes cause, or result from, hepatic damage.