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OESTRADIOL BINDING ACTIVITY IN RAT LIVER TUMOURS AND IN HUMAN HEPATOCELLULAR CARCINOMA
Author(s) -
Alagaratnam T. T.,
And W. Wei,
Wong J.
Publication year - 1987
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1987.tb01402.x
Subject(s) - hepatocellular carcinoma , medicine , cytosol , scatchard plot , human liver , carcinoma , receptor , hormone , endocrinology , pathology , biochemistry , biology , in vitro , enzyme
Oestradiol binding activity was studied in normal liver tissues of rats as well as in experimentally induced liver tumours by incubating a cytosol prepared from the tissue with radioactive oestradiol. The free radioactive hormone was absorbed by a dextran‐charcoal suspension, and the amount required to saturate the receptors was calculated by a scatchard plot. Similar activity was observed in normal human liver as well as in naturally occurring hepatocellular carcinoma.