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CLINICAL TRIAL OF PROPHYLAXIS OF WOUND SEPSIS IN ELECTIVE COLORECTAL SURGERY COMPARING TICARCILLIN WITH TINIDAZOLE
Author(s) -
Ryan Mr. P. J.,
Fink R. L. W.,
Coordinator Mr. H. RossTrial,
Allsop Mr. J. R.,
Andrew Dr. J. H.,
Bennettt Professor R. C.,
Braithwaitte Mr. P. A.,
Carson Mr. P.,
Collins Mr. J. P.,
Collopy Mr. B. T.,
Cuthberston Mr. A.M.,
Ewing Mr. H.,
Forbes Mr J. F.,
Francis Mr. D. M.,
Gray Mr. B. N.,
Hardy Professor K. J.,
Harvey Dr. K.,
Jones Mr. T.,
Judson Mr. R. T.,
Kune Professor G. A.,
Mackay Mr. J. R.,
McLeish Mr. A. R.,
Martin Mr. C. J.,
Millar Mr. K. J.,
Pavillard Dr. E. R.,
Penfold Mr. J. C. B.,
Read Mr. A. E.,
Sali Mr. A.,
Tosolini Dr. F. A.
Publication year - 1986
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1986.tb06137.x
Subject(s) - medicine , ticarcillin , tinidazole , antibiotic prophylaxis , colorectal surgery , surgery , randomized controlled trial , anaerobic bacteria , antibiotics , anesthesia , clavulanic acid , abdominal surgery , amoxicillin , metronidazole , microbiology and biotechnology , genetics , bacteria , biology
A prospective randomized single blind controlled clinical trial was undertaken to compare prophylactic therapy using a systemic antibiotic active against both aerobic and anaerobic bacteria with an oral antibiotic agent active only against anaerobic bacteria in elective colorectal surgery. One hundred and thirty‐one patients received ticarcillin and 130 received tinidazole. The wound infection rate was 8% in those patients receiving ticarcillin prophylaxis and 20% in those receiving tinidazole (P < 0.05). Multivariate analysis of the factors affecting wound infection rate showed that there were three independent factors that reached statistical significance: the prophylactic antibiotic used; the type of hospital (public or private) in which the operation was performed, and the presence of a stoma at operation. The wound infection rate in those patients receiving tinidazole prophylaxis was more than twice that reported previously by the authors. The mortality in patients receiving ticarcillin prophylaxis was 1.5% compared to 9.2% in those receiving tinidazole prophylaxis (P < 0.05). The clinical anastomotic leakage rate was similar in each antibiotic prophylactic group, 8.6% in those receiving ticarcillin and 7.3% in those receiving tinidazole.