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SERUM BILIRUBIN AFTER SURGERY FOR OBSTRUCTIVE JAUNDICE
Author(s) -
Little J. M.,
Robotin M.
Publication year - 1986
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1986.tb01816.x
Subject(s) - medicine , bilirubin , jaundice , obstructive jaundice , serum bilirubin , biliary drainage , gastroenterology , direct bilirubin , enzyme , biochemistry , chemistry , alkaline phosphatase
A method of analysis of bilirubin clearance is suggested, which allows the claculation of a decay constant ( k ) and half‐life ( t 0·5 ). These parameters allow ready comparison of the bilirubin clearance between patient groups. The value of k could be predicted with reasonable accuracy by a regression equation employing as determinants a score for cholangitis, pre‐operative serum ALT and bilirubin, and the patient's sex. Bilirubin clearance is kniwn to correlate strongly with antipyrine clearance, and antipyrine clearance with prognosis after biliary drainage. A similar prognostic index may be derived from simple clinical and biochemical parameters which will predict the decay constant and half‐life of endogenous bilirubin.