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HIGH SERUM LEVELS OF ALKALINE PHOSPHATASE ARE ASSOCIATED WITH CANCER IN CHOLESTATIC JAUNDICE
Author(s) -
Wilson J. W.,
Kronborg I. J.,
RobertsThomson I. C.
Publication year - 1985
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1985.tb00922.x
Subject(s) - medicine , alkaline phosphatase , bile duct cancer , jaundice , gastroenterology , cancer , liver function tests , cholestasis , liver cancer , bile duct , obstructive jaundice , elevated alkaline phosphatase , cholestatic jaundice , prospective cohort study , enzyme , biochemistry , chemistry
In a prospective study of liver function tests in cholestatic jaundice, the median serum level of alkaline phosphatase (ALP) in 129 patients with cancer involving ektrahepatic ducts and liver (556 IU/l) was significantly higher ( P < 0.001) than that in 121 patients without cancer (264 IU/1). Of patients with an ALP level of greater than 10 x N, 88% had cancer whereas serum levels of ALP of less than 3 x N were observed in only 9% of patients with cancer but in 45% of those without cancer, most of whom had bile duct stones. A high serum level of ALP is associated with cancer involving extrahepatic ducts and liver.