Premium
THE MANAGEMENT OF METASTATIC GERM CELL TUMOURS AND THE CLINICAL UTILITY OF LACTATE DEHYDROGENASE ESTIMATIONS
Author(s) -
Gill P. Grantley,
Abbott Richard,
Jones Alan M.,
Thomas David W.
Publication year - 1985
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1985.tb00872.x
Subject(s) - medicine , lactate dehydrogenase , chemotherapy , ovary , teratoma , germ cell , germ cell tumors , pathology , gastroenterology , enzyme , surgery , biochemistry , chemistry , gene
Forty‐five patients with metastatic germ cell tumour were treated with chemotherapy. Complete remission was achieved in 63% of all cases and in 65% of patients whose primary tumour arose in the testis or ovary. Surgical resection of abdominal masses persisting after chemotherapy was performed in seven patients, two of whom were found to have persistent tumours. Twenty‐seven of the 33 patients with teratoma originating in the gonads remain in complete remission. Total serum LDH activity was elevated in 28 of the patients with measurable disease. The increased LDH was not accompanied by significant alteration in other hepatic enzymes nor were hepatic metastases demonstrable in these patients. Fractionation of the LDH demonstrated that the increased LDH in these patients was located in either iso‐enzymes 1 or fractions 1 + 2. Alteration of the serum LDH activity correlated with the response to therapy and warrants further study.