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WOUND INFECTION IN ELECTIVE BILIARY SURGERY: CONTROLLED TRIAL USING ONE DOSE CEPHAMANDOLE *
Author(s) -
Kune Gabriel A.,
Hunt Roland F.,
Jed Andrew,
Lusink Christopher,
Mclaughlin Stephen,
Carson Peter
Publication year - 1985
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1985.tb00848.x
Subject(s) - medicine , placebo , wound infection , surgery , biliary tract surgical procedures , placebo group , elective surgery , randomized controlled trial , biliary tract , pathology , alternative medicine
In aprospective randomized double‐blind trial using a 1 g single dose of cephamandole versus placebo, given I h before surgery, the wound infection rate after elective surgery for gallbladder stones in 200 consecutive cases was 11%, being 15% in the placebo group and 7% in the cephamandole group (x 2 = 4.03; P <0.05). The average hospital stay was 7.7 days in the absence of wound infection and 13.6 days in the presence of wound infection. Contaminated bile was significantly positively related to wound infection, and cephamandole significantly protected the culture‐positive group from wound infection.