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OESTRADIOL RECEPTOR VALUES IN BREAST CANCER AND RESPONSE OF METASTASES TO THERAPY *
Author(s) -
Bryan Robert M.,
Mercer Ronald J.,
Bennett Richard C.,
Rennie George C.,
Lie Tat Hean,
Morgan Francis J.
Publication year - 1984
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1984.tb06675.x
Subject(s) - medicine , breast cancer , oncology , cancer , gynecology
Eighty‐one women who had received hormonal therapy for advanced disease were assessed for objective response to treatment. Another 73 patients who had received chemotherapy were similarly studied. Patients with ER ‐ tumours had a significantly poorer response rate to hormonal therapy than those with ER+ tumours (P < 0.05) and a significant trend toward an increasing rate of response occurred with increasing quantitative levels of receptor (P < 0.01). This trend was even more significant when the assay had been performed on recurrent tumour (P < 0.001), suggesting that this provides a more accurate index of response to hormonal treatment than assays performed on the primary lesion. These results suggest that whilst the quantitative receptor level used to discriminate between ‘negative’ or ‘positive’ assays is appropriate, this division is an over‐simplification. Oestrogen receptor was not helpful in predicting response to chen. therapy.