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ALTERED BLOOD LYMPHOCYTE SUBCLASSES IN PATIENTS WITH ULCERATIVE COLITIS
Author(s) -
Learmonth R. P.,
Pihl E.,
Johnson W. R.,
Barnett M. A.,
McDermott F. T.,
Hughes E. S. R.
Publication year - 1984
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1984.tb05315.x
Subject(s) - medicine , ulcerative colitis , monoclonal antibody , lymphocyte , dysplasia , immunology , t lymphocyte , lymphocyte subsets , antibody , cytotoxic t cell , peripheral blood , disease , immune system , cd8 , biology , in vitro , biochemistry
Peripheral blood lymphocytes were studied by flow cytofluorimetry and monoclonal antibody techniques in 107 patients with ulcerative colitis and in 20 healthy controls of similar ages. Total T, T helper (T H ), and T cytotoxic/suppressor (T c/s ) lymphocytes were defined by the monoclonal antibodies OKT3, OKT4 and OKT8, respectively, while B lymphocytes were defined by surface immunoglobulin. Patients had a significantly ( P < 0.05) lower proportion of T c/s lymphocytes than the controls, and patients with quiescent disease had a reduced proportion of B lymphocytes compared to controls and those with active disease. Patients with marked mucosal dysplasia had a significantly ( P < 0.025) lower proportion of T H lymphocytes and a higher ( P < 0.01) proportion of B lymphocytes than those without dysplasia. There were no significant associations between lymphocyte levels and any other clinicopathological features assessed.