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A DOUBLE‐BLIND CROSSOVER STUDY OF THE EFFECT OF LOPERAMIDE HYDROCHLORIDE AND CODEINE PHOSPHATE ON ILEOSTOMY OUTPUT
Author(s) -
KING RODERICK F. G. J.,
NORTON THOMAS,
HILL GRAHAM L.
Publication year - 1982
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1982.tb06083.x
Subject(s) - loperamide , ileostomy , medicine , crossover study , codeine , anesthesia , pharmacology , diarrhea , gastroenterology , morphine , placebo , alternative medicine , pathology
Loperamide hydrochloride (4 mg t.d.s.) was compared with codeine phosphate (60 mg t.d.s.) in a double blind crossover study of patients with loose output from their ileostomies. Both drugs significantly decreased the daily output and water content of ileostomy fluid. Daily losses of sodium and potassium were less when the patients were treated with loperamide. Loperamide was also associated with less side effects. It is concluded that loperamide hydrochloride was more effective in the treatment of ileostomy diarrhoea than codeine phosphate. In this group of patients those with the highest outputs from their ileostomies benefited most from this treatment.