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THE EFFECT OF FLUOROURACIL ON SURVIVAL IN METASTATIC COLORECTAL CANCER FLUOROURACIL RESPONSE IMPROVES SURVIVAL
Author(s) -
PAYNE J. E.,
PHEILS M. T.,
CHAPUIS P. H.,
MACPHERSON J. G.
Publication year - 1981
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1981.tb05893.x
Subject(s) - medicine , fluorouracil , colorectal cancer , chemotherapy , stage (stratigraphy) , survival rate , oncology , gastroenterology , surgery , cancer , paleontology , biology
We set out to define the place for therapy with fluorouracil in patients with advanced colorectal cancer. Sixty‐three patients with stage D 2 cancers were observed for seventeen months to five years from the time of diagnosis. Thirty patients received fluorouracil in various regimens. Nineteen patients were not referred for chemotherapy, a further eleven were excluded because their condition was terminal, and three could not be evaluated. Ten patients had either partial or complete response to fluorouracil; their median survival was 25 months. Twenty patients who did not respond to fluorouracil had a median survival of 11 months, whereas the non‐treated group had a median survival of 15 months. The difference between the responders and the of her groups was highly significant.