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PREVENTION OF WOUND INFECTION IN ELECTIVE COLORECTAL RESECTIONS BY PREOPERATIVE CEPHAZOLIN WITH AND WITHOUT METRONIDAZOLE
Author(s) -
MCDERMOTT F. T.,
POLGLASE A. L.,
JOHNSON W. R.,
HUGHES E. S. R.
Publication year - 1981
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1981.tb04963.x
Subject(s) - medicine , metronidazole , chemoprophylaxis , placebo , wound infection , surgery , incidence (geometry) , colorectal surgery , anesthesia , resection , antibiotics , abdominal surgery , physics , alternative medicine , optics , pathology , microbiology and biotechnology , biology
Fifty patients were admitted to a prospective controlled double blind trial for assessment of the effect of preoperative intramuscular cephazolin with oral metronidazole or placebo on the incidence of wound infection in patients requiring treatment by elective large intestinal resection. All patients were operated upon by one surgeon. After exclusion of two patients who died postoperatively 48 were analysed. No wound infection occurred In 22 patients receiving cephazolin with metronidazole. One (3.8%) infection developed in 26 patients receiving cephazolin with placebo. The difference did not attain statistical significance. Preoperative intramuscular cephazolin with or without metronidazole provides an effective and safe method of chemoprophylaxis for elective colorectal resection.