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LIGHT AND ELECTRON MICROSCOPY OF POLYTETRAFLUOROETHYLENE ARTERIAL GRAFTS IN DOGS
Author(s) -
Brook Wilfrid H.,
Phornphibulaya Pramot,
Scott David F.
Publication year - 1980
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1980.tb04215.x
Subject(s) - polytetrafluoroethylene , vasa vasorum , medicine , connective tissue , fibrin , electron microscope , neointima , anatomy , fibril , endothelium , aorta , collagen fibril , pathology , surgery , biophysics , materials science , composite material , optics , restenosis , physics , endocrinology , biology , stent , immunology
Reinforced expanded polytetrafluoroethylene grafts with fibril lengths of approximately 17 to 25 µm were inserted into the infrarenal aorta of dogs for periods ranging from 24 hours to eight months. The grafts were studied by light and electron microscopy, which showed that polytetrafluoroethylene consists 01 ridges or nodes connected by fibrils. Initially red blood cells passed down in the pores of the polytetrafluoroethylene, and then the surface was covered with fibrin. A new endothelium developed by the twelfth day. The new intimal lining became thicker owing to the appearance of smooth muscle cells deep to the endothelial cells, forming a neointima 120 µm thick by eight months. Fibroblasts and collagen penetrated the graft, but vasa vasorum did not, although they were present in the external connective tissue.