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THE PROTECTIVE EFFECT OF CIMETIDINE ON STRESS‐INDUCED ACUTE GASTRIC ULCERATION IN THE RAT
Author(s) -
KING R. W. F.,
KORMAN M. G.,
TAGGART G. J.,
HANSKY J.
Publication year - 1979
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1979.tb06459.x
Subject(s) - medicine , cimetidine , stress ulcer , gastroenterology
The effect of intraperitoneal cimetidine, an H 2 receptorantagonist, has been assessed on the development of cold‐restraint induced acute gastric ulcers in rats. Cimetidine in doses ranging from 20–100 mg per kg body weight significantly reduced the incidence of acute gastric ulceration compared with saline controls in this model. The protective effect of cimetidine suggests a prophylactic role for this agent in stress‐induced gastric or duodenal ulceration in man.