Premium
A Simple Method of Measuring Host Immune Rejection Response After Renal Transplantation 1
Author(s) -
Hunt P.,
Scott D.,
Trotter S.,
Atkins R.
Publication year - 1973
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1973.tb07340.x
Subject(s) - medicine , transplantation , thymidine , immune system , peripheral blood , lymphocyte , kidney transplantation , urine , urology , surgery , immunology , in vitro , biochemistry , chemistry
The 3‐hour uptake of tritiated thymidine ( 3 HT) is a simple reproducible estimation of spontaneous lymphocyte activation in the peripheral blood as evidenced by the constancy of results in control studies. Three patterns in 3 HT uptake were seen in 13 patients after renal transplantation. Four patients without clinical evidence of rejection at one year had normal daily uptakes during the 3 weeks after transplantation. In another group of 5 patients, uptakes were initially normal before a rise in uptake of more than 100%, on consecutive days antedating a clinical rejection episode. In the other group of 4 patients, there was a significant rise in uptake of 2 HT from the day of grafting, which resulted in the loss of the graft on 3 occasions.