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Penicillin and Local Recurrence of Carcinoma in Large‐Bowel Surgery
Author(s) -
HARDY K. J.,
HUGHES E. S. R.,
CUTHBERTSON A. M.
Publication year - 1973
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1973.tb06802.x
Subject(s) - medicine , penicillin , mortality rate , surgery , anastomosis , carcinoma , suture line , antibiotics , microbiology and biotechnology , biology
The incidence of local recurrence, including suture‐line recurrence, has been analysed with reference to chemoprophylaxis in 277 patients having a curative large‐bowel resection and anastomosis for carcinoma between 1961 and 1968. Ninety‐five patients received penicillin, the local recurrence rate being 10.5% and the death rate from carcinoma 23.1%, 105 received neomycin, with a 7.6% local recurrence rate and a 25.8% death rate, and 77 received no antibiotic, with a 10.4% local recurrence rate and a 23.3% death rate. There was not any significant difference between the three groups.