Premium
The Effect of Phytohæmagglutinin and Cyclophosphamide on the Incidence of Mammary Tumours in Rats
Author(s) -
HUNT P. S.,
HOLYOKE E. D.,
PERLMUTTER R.
Publication year - 1972
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1972.tb06753.x
Subject(s) - medicine , cyclophosphamide , incidence (geometry) , dmba , mammary gland , physiology , endocrinology , chemotherapy , cancer , breast cancer , carcinogenesis , physics , optics
The later incidence of DMBA (7, 12 dimethylbenz (a)anthracine)‐induced mammary tumours in Sprague Dawley rats is significantly reduced by parenteral administration of phytohæmagglutinin (PHA), with or without cyclophosphamide. Cyclophosphamide alone increases tumour incidence, but this increase is not statistically significant.