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Hormonal Imbalance and the Sarcomata 1
Author(s) -
Starr Kenneth W.
Publication year - 1969
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1969.tb05577.x
Subject(s) - medicine , hormone , population , endocrinology , physiology , gynecology , environmental health
A series of 11 patients suffering front sarcoma of either soft tissues or bone, and of various ages (2–92 years), has been studied in our Unit. It was observed that in the majority of the postpubertal patients the serum level of human growth hormone (HGH, STH, somatotrophin) was elevated above the mean figure for the Australian population, estimated by radio‐immuno‐assay. This figure is 2.4 γγ/ml serum, with a range of 0.3–7.7 γγ/ml (Lazarus). In the sarcomatous patients, this level was exceeded in six of the nine postpubertal adults, but not in the prepubertal children, or in the very aged, or in those with quiescent lesions. Clinical improvement varying from regression to total disappearance was observed when the raised serum level was promptly reduced to lower levels.