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CORTICOID REPLACEMENT AFTER ADRENALECTOMY WITH SPECIAL REFERENCE TO THE USE OF FLUOROHYDROCORTISONE
Author(s) -
Woodruff M. F. A.,
Llaurado J. G.,
Pearse V. T.
Publication year - 1957
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1957.tb06389.x
Subject(s) - cortisone , medicine , desoxycorticosterone acetate , fludrocortisone , adrenalectomy , mineralocorticoid , endocrinology , adrenogenital syndrome , glucocorticoid , cortisone acetate , bilateral adrenalectomy , hydrocortisone
Summary Neither cortisone nor 9α‐fluorohydrocorti‐sone acetate alone provides adequate steroid replacement in adrenalectomised patients: cortisone because its mineralocorticoid action is insufficient in comparison with its glucocorticoid action, and 9α‐fluorohydrocortisone acetate because the converse is true. By using both these steroids a proper balance can be achieved. One patient, who has been studied in detail for a year following bilateral adrenalectomy, is being satisfactorily maintained with 0.1 mg. 9α‐fluorohydrocortisone acetate and 20 mg. cortisone twice daily by mouth.