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PHE LOCAL USE OF SULPHONAMIDE COMPOUNDS. 1
Author(s) -
WILSON T. E.
Publication year - 1942
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1942.tb02900.x
Subject(s) - medicine , granulation , granulation tissue , sulfathiazole , surgery , pathology , microbiology and biotechnology , biology , physics , wound healing , classical mechanics
S ummary .As judged by a clinical trial in more than one hundred patients, the local application of sulphanilamide to wounds, ulcers, burns and skin grafts is often of considerable value. Sulphapyridine, sulphathiazole and sulphanilamide were implanted in the tissues and body cavities of one hundred rats. Seventeen rats were used as controls. Prom these experiments it may be concluded that only extremely large amounts of these drugs produce deleterious effects on the tissues, and that lesser amounts do not inhibit reparative processes. Because solid sulphapyridine is rapidly walled off by granulation tissue, this drug is much less suitable for local application than sulphanilamide. Sulphathiazole, having a solubility intermediate between those of sulphanilamide and of sulphapyridine and only rarely being walled off by granulation tissue, is indicated for local application when delay in absorption is desirable or when the special effects of sulphathiazole are necessary. Local chemotherapy is not advisable for the treatment of diffuse pleural or peritoneal infections. No significant differences were found in the blood or bone marrow of a small series of rats in which sulphapyridine was implanted.