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Expression of p 53, p 16 and cyclooxygenase‐2 in esophageal cancer with tissue microarray
Author(s) -
LIU You Shi,
YU Chao Hui,
LI Lan,
ZHANG Bao Feng,
FANG Jing,
ZHOU Qiong,
HU Ying,
LI You Ming,
Jun GAO Hen
Publication year - 2007
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1443-9573.2007.00299.x
Subject(s) - tissue microarray , esophageal cancer , medicine , proportional hazards model , immunohistochemistry , carcinogenesis , cancer , clinical significance , pathology , microarray analysis techniques , oncology , logistic regression , biomarker , gene expression , biology , gene , biochemistry
OBJECTIVE: The aim of this study was to obtain a comprehensive survey on the expression of p 53, p 16 and cyclooxygenase‐2 (COX‐2) in esophageal cancer progression and their clinical significance. METHODS: A tissue microarray containing 86 specimens from esophageal cancer and 40 specimens from adjacent non‐cancer tissue was constructed to survey the expression of p 53, p 16 and COX‐2 by immunohistochemistry. The influence of each biomarker on the histotype of esophageal lesion was assessed by logistic regression analysis. RESULTS: The expression of p 53 and COX‐2 was significantly higher in tumorous tissue than in non‐tumorous tissue. As to p 16, no significant difference was detected between tumorous and non‐tumorous tissue. A significant correlation was observed among p 53, COX‐2 and p 16 expression. Logistic regression analysis revealed that the risk factors of a tumorous histotype were the positive expression of p 53 (odds ratio [ OR ] = 18.214) or COX‐2 ( OR = 42.703), and no reciprocal relationship to neoplastic progression was recognized with p 53, p 16 and COX‐2. CONCLUSIONS: p 53 and COX‐2 were independent predictors in esophageal carcinogenesis. Esophageal tissue with a positive expression of p 53 or COX‐2 was more likely to develop esophageal cancer.